Beta-keto-amide derivatives useful as ion channel modulators

A β-keto-amide derivative of Formula I

• a stereoisomer or a mixture of its stereoisomers, or a pharmaceutically acceptable addition salt thereof, wherein
• R1 represents a tetrazolyl or a 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl group;
• R2 represents halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy or phenyl, which phenyl is optionally substituted one or more times with halo, trifluoromethyl, trifluoromethoxy and/or hydroxy;
• and
• R3 represents hydrogen, halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy or phenyl, which phenyl is optionally substituted one or more times with halo, trifluoromethyl, trifluoromethoxy and/or hydroxy;
• or
• R2 represents hydrogen;
• and
• R3 represents halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy or phenyl, which phenyl is optionally substituted one or more times with halo, trifluoromethyl, trifluoromethoxy and/or hydroxy;
• and
• R4 and R5, independently of each other, represent halo, trifluoromethyl, trifluoromethoxy or phenyl.