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US 2010/0137381 A1Published application
Acetamide derivatives as potassium channel modulators
AssigneeNeuroSearch A/S
InventorsAntonio Nardi, Morten Grunnet, Palle Christophersen, Joachim Demnitz, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
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Abstract
This invention relates to novel acetamide derivatives that are found to be potent modulators of ion channels, in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
Claims9
1-9. (canceled)
An acetamide derivative of Formula I
- a stereoisomer or a mixture of its stereoisomers, or a pharmaceutically-acceptable addition salt thereof, wherein
- R1 represents a tetrazolyl, an N-hydroxy-carbamimidoyl or a 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl group;
- R2 represents halo, trifluoromethyl or phenyl, which phenyl may optionally be substituted one or two times with halo, trifluoromethyl, trifluoromethoxy and/or N,N-dialkylsulfamoyl;
- and
- R3 and R4, independently of each other, represent hydrogen, halo or trifluoromethyl hydroxy, alkylsulfonyl or SO2NR′R″, wherein R′ and R″ represents hydrogen or alkyl, or R′ and R″, together with the N-atom to which they are attached, form a heterocyclic ring selected from piperidine, piperazine and morpholine.
2 more elements
Dependencies are inferred from the claim text.