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US 2010/0137351 A1Published application
Imidazoacridinone derivative compounds and methods for their use
AssigneeTechnion Research & Development Foundation Limited
InventorsYehuda G. Assaraf, Eran E. Bram, Yamit Bney-Moshe, Andrzej M. Skladanowski
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Abstract
The present invention provides IA derivative compounds of the formula: where the variables are described herein.
Claims24
A method of testing a compound for activity against cancer or an autoimmune condition, comprising testing a compound of the formula
- wherein:
- R1, R2, R3 and R6 are, independently, selected from the group consisting of hydrogen, halogen, hydroxy, C1 to C6 alkyl, C1 to C6 substituted alkyl, oxo, amino, protected amino, (monosubstituted)amino, (disubstituted)amino, C1 to C6 alkoxy, C1 to C6 substituted alkoxy, C1 to C6 acyl, C1 to C6 acyloxy, nitro, carboxy, carbamoyl, carboxamide, cyano and thiol;
- R14, Ra and Rb are, independently, selected from the group consisting of hydrogen, C1 to C12 alkyl and C1 to C12 substituted alkyl;
- and
- n is 1 to 30;
- provided that, when a) n is less than 6;
- or b) Ra and Rb together include less than 5 carbon atoms, none of R1, R2 and R3 is hydroxyl.
4 more elements
A method of improving the status of a subject with cancer or an autoimmune condition, comprising administering to said subject a compound of the formula
- wherein:
- R1, R2, R3 and R6 are, independently, selected from the group consisting of hydrogen, halogen, hydroxy, C1 to C6 alkyl, C1 to C6 substituted alkyl, oxo, amino, protected amino, (monosubstituted)amino, (disubstituted)amino, C1 to C6 alkoxy, C1 to C6 substituted alkoxy, C1 to C6 acyl, C1 to C6 acyloxy, nitro, carboxy, carbamoyl, carboxamide, cyano and thiol;
- R14, Ra and Rb are, independently, selected from the group consisting of hydrogen, C1 to C12 alkyl and C1 to Cit substituted alkyl;
- and
- n is 1 to 30;
- provided that, when a) n is less than 6;
- or b) Ra and Rb together include less than 5 carbon atoms, none of R1, R2 and R3 is hydroxyl.
4 more elements
A compound of the formula:
- wherein:
- R1, R2, R3 and R6 are, independently, selected from the group consisting of hydrogen, halogen, hydroxy, C1 to C6 alkyl, C1 to C6 substituted alkyl, oxo, amino, protected amino, (monosubstituted)amino, (disubstituted)amino, C1 to C6 alkoxy, C1 to C6 substituted alkoxy, C1 to C6 acyl, C1 to C6 acyloxy, nitro, carboxy, carbamoyl, carboxamide, cyano and thiol;
- R14, Ra and Rb are, independently, selected from the group consisting of hydrogen, C1 to C12 alkyl and C1 to C12 substituted alkyl;
- and
- n is 1 to 30;
- provided that, when a) n is less than 6;
- or b) Ra and Rb together include less than 5 carbon atoms, none of R1, R2 and R3 is hydroxyl.
4 more elements
Dependencies are inferred from the claim text.