Metabolites of (thio) carbamoyl-cyclohexane derivatives
AssigneeRichter Gedeon Nyrt.
InventorsEva Againe Csongor, Norbert Antal Kirschner, Eva Schmidt, Istvan Gyertyan, Bela Kiss
Life of this patent
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Abstract
The present invention relates to metabolites of (thio)carbamoyl cyclohexane derivatives, particularly, metabolites of trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimemylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing the same and to their use in the treatment and/or prevention of a conditions which requires modulation of dopamine receptors.
Claims26
An isolated metabolite of a compound of formula (I):
- wherein
- R1 and R2 are each, independently, hydrogen, alkyl, alkenyl, aryl, cycloalkyl, aroyl, or R1 and R2 form a heterocyclic ring with the adjacent nitrogen atom;
- X is O or S;
- n is 1 or 2;
- and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof.
An isolated and/or synthetized compound of formula (II):
- wherein
- R1 and R2 are each, independently, hydrogen, alkyl, alkenyl, aryl, cycloalkyl, aroyl or R1 and R2 form a heterocyclic ring with the adjacent nitrogen atom;
- X is O or S;
- n is 1 or 2;
- and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof.
An isolated and/or synthetized compound of formula (III):
- wherein
- R1 and R2 are each, independently, hydrogen, alkyl, alkenyl, aryl, cycloalkyl, aroyl, or R1 and R2 form a heterocyclic ring with the adjacent nitrogen atom;
- X is O or S;
- n is 1 or 2;
- and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof.
A pharmaceutical composition comprising an isolated metabolite of a compound of formula (I):
- wherein
- R1 and R2 are each, independently, hydrogen, alkyl, alkenyl, aryl, cycloalkyl, aroyl, or R1 and R2 form a heterocyclic ring with the adjacent nitrogen atom;
- X is O or S;
- n is 1 or 2;
- and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof and one or more pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound of formula (II)
- wherein
- R1 and R2, are each, independently, hydrogen, alkyl, alkenyl, aryl, cycloalkyl, or aroyl, or R1 and R2 form a heterocyclic ring with the adjacent nitrogen atom;
- X is O or S;
- n is 1 or 2;
- and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof and one or more pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound of formula (III):
- wherein
- R1 and R2, are each, independently, hydrogen, alkyl, alkenyl, aryl, cycloalkyl, or aroyl, or R1 and R2 form a heterocyclic ring with the adjacent nitrogen atom;
- X is O or S;
- n is 1 or 2;
- and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof and one or more pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.