Quinoxaline Compounds and Use Thereof

A quinoxaline compound according to the following Formula (I)

• wherein:
• R1 is selected from H;
• or C1-C6alkyl;
• R2 is selected from (CH2)m-R4, (CH2)m-CH(R4)2, CH(R4)2, CH((CH)2mOH)2, CH((CH)2m-C1-C6 alkoxy)2, CO—R4′ or SO2—R4′;
• R3 is selected from C1-C6alkyl;
• C3-C8 cycloalkyl;
• C3-C8 heterocycloalkyl;
• C6-C18 aryl;
• and C3-C18 hetero aryl group;
• (CH2)m-S—C1-C6alkyl;
• (CH2)m-SO2—C1-C6alkyl;
• or (CH2)m-C1-C6alkoxy;
• wherein aryl and heteroaryl groups may also be substituted by one or more of the following groups:
• C1-C6alkyl;
• C1-C6alkoxy;
• NH2, NH—(C1-C6 alkyl), N(C1-C6 alkyl)2, (CH2)mNH2, (CH2)mNH—(C1-C6 alkyl), (CH2)mN(C1-C6 alkyl)2, (CH2)mOH, (CH2)m-(C1-C6 alkoxy), halogen, CN, NHCO(CH2)mOH, NHCO(CH2)m-(C1-C6 alkoxy), or C3-C8 heterocycloalkyl;
• or R3 is the following group:
• wherein:
• X1 is CH or N;
• X2 is CH2, O, S, SO2, NH, NQY, or CHOQY;
• Q is (CH2)p, (CH2)pCO(CH2)p′, or (CH2)pSO2(CH2)p′;
• Y is H, C1-C6 alkyl, C1-C6 alkoxy, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, OCH2aryl, or Oaryl
• p, p′ is independently 0, 1, 3, 4, 5 or 6;
• R4 is selected from hydroxy;
• C1-C6 alkoxy;
• CH(OH)(CH2)mOH, N((CH2)mOH)C1-C6 alkyl, OCONH(C1-C6 alkyl), NH2, NH—(C1-C6 alkyl), N(C1-C6 alkyl)2, NH—CO—(C1-C8 alkyl), NH—SO2—(C1-C8 alkyl), NH(CH2)m-OH, NH—(CH2)m-(C1-C6 alkoxy), N(C1-C6 alkyl)(CH2)mOH, N(C1-C6 alkyl)(CH2)m(C1-C6 alkoxy), N((CH2)mOH)C1-C6 alkyl, SO2—(C1-C6 alkyl), C3-C8 cycloalkyl;
• C3-C8 heterocycloalkyl;
• OCOCH(NH2)(C1-C6 alkyl), OCOCH(C1-C6alkyl)NHCOOCH2-(9H-fluoren-9-yl) or the following group:
• wherein:
• X1, X2, Q, Y, and p are as defined above for R3;
• and
• W1, W2, W3, W4 are H or CH3, and Wand W3 together may also be CH2CH2;
• R4′ is selected from C1-C6 alkoxy;
• CH(OH)(CH2)mOH, N((CH2)mOH)C1-C6 alkyl, NH2, NH—(C1-C6 alkyl), N(C1-C6 alkyl)2, NH(CH2)m-OH, NH—(CH2)m-(C1-C6 alkoxy), N(C1-C6 alkyl)(CH2)mOH, N(C1-C6 alkyl)(CH2)m(C1-C6 alkoxy), N((CH2)mOH)C1-C6 alkyl, C3-C8 cycloalkyl;
• C3-C8 heterocycloalkyl;
• or the following group:
• wherein:
• X1, X2, Q, Y, W1, W2, W3, W4 and p are as defined above;
• m is an integer selected from 1 to 6;
• or geometrical isomers, enantiomers, diastereomers, tautomers, racemates thereof, and pharmaceutically acceptable salts thereof.

A compound of formula (II) selected from the following group:

• 4-{[(3-chloroquinoxalin-2-yl)amino]sulfonyl}-N,N-dimethylbenzamide;
• N-(3-chloroquinoxalin-2-yl)-4-fluorobenzenesulfonamide;
• N-(3-chloroquinoxalin-2-yl)pyridine-3-sulfonamide;
• N-(3-chloroquinoxalin-2-yl)methanesulfonamide;
• or
• N-(3-chloroquinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide.