Compositions for the Treatment and Prevention of Heart Disease and Methods of Using Same
OwnerJonathan S. Stamler, Gregory T. Wentinventors
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Abstract
The combination of nitric oxide generating compounds which are not dependent upon aldehyde dehydrogenase for bioactivation, or are specifically targeted to nNOS or the sarcoplasmic reticulum of cardiac muscle cells, and xanthine oxidase inhibitors are effective in the treatment of heart disease, specifically congestive heart failure and ischemic coronary disease. This treatment is particularly effective in patients who have particularly heavy oxidative burdens, e.g. diabetics, patients with lung disorders, patients with sickle cell anemia and patients of Asian descent.
Claims33
A pharmaceutical composition comprising one or more xanthine oxidase inhibitors and one or more nitric oxide generating compounds, wherein the nitric oxide generating compounds do not interact with aldehyde dehydrogenase in a manner which increases ocidative stress or the nitric oxide generating compounds enhance the activity of or the expression of neuronal nitric oxide synthase.
A method of treating or preventing a cardiac pathology in a subject in need thereof, the method comprising administering to the subject a pharmaceutically acceptable dose of one or more xanthine oxidase inhibitors and one or more nitric oxide generating compounds, wherein the nitric oxide generating compounds do not interact with aldehyde dehydrogenase in a manner which increases oxidative stress or the nitric oxide generating compounds enhance the activity of or the expression of neuronal nitric oxide synthase, thereby treating or preventing the cardiac pathology in the subject in need thereof.
A kit for treating or preventing a cardiac pathology in a subject in need thereof, comprising a therapeutically effective dose of one or more nitric oxide generating compounds, wherein the one or more nitric oxide generating compounds do not interact with aldehyde dehydrogenase in a manner which increases oxidative stress or the one or more the nitric oxide generating compounds enhance the activity of or the expression of neuronal nitric oxide synthase, either in the same or separate packaging, and instructions for its use.
Dependencies are inferred from the claim text.