6"-amino-6"-deoxygalactosylceramides
AssigneesThe Scripps Research Institute, Brigham Young University, The University of Chicago
InventorsPaul B. SAVAGE, Albert Bendelac, Luc Teyton
Life of this patent
Estimating the term…
Abstract
This invention relates to galactosylceramide compounds.
Claims20
1-19. (canceled)
A method of stimulating the immune system of a subject in need of such stimulation, the method comprising administering a compound of Formula (I) to the subject wherein the compound of Formula (I) comprises:
- wherein,
- R1 is —C(O)R10, wherein R10 is C1-C12 alkyl optionally substituted with carboxyl;
- R2 is hydrogen;
- R3, R4, R5, R6 and R7 are each hydrogen;
- R8 is —(CH2)x(CH3;
- R9 is a linear or branched C3-C100 alkyl;
- and
- x is 1-100.
A method of treating an autoimmune disease in a subject in need of such treatment, the method comprising administering an effective amount of a compound of Formula (I) to the subject wherein the compound of Formula (I) comprises:
- wherein,
- R1 is —C(O)R10, wherein R10 is C1-C12 alkyl optionally substituted with carboxyl;
- R2 is hydrogen;
- R3, R4, R5, R6 and R7 are each hydrogen;
- R8 is —(CH2)xCH3;
- R9 is a linear or branched C3-C100 alkyl;
- and
- x is 1-100.
24-25. (canceled)
The method of claim 37, wherein R8 is —(CH2)24CH3.
Dependencies are inferred from the claim text.