Novel ligand guided block copolymers for targeted drug delivery

A compound of formula I:

• wherein
• M1 is a linker group selected from the group consisting of a single bond, a methyl group, an ethyl group, a propyl group or a C4-10alkyl group;
• P1 is CH3, a reactive functional group or a targeting moiety;
• L1 is a linker group selected from the group consisting of a single bond, —C(O)—O—, —C(O)— and —C(O)NHR2;
• R1 is selected from the group consisting of H, OH, hydrazone, polyamine, polyamine-CF3, protected polyamine, C1-20alkyl, C3-20cycloalkyl and aryl, said latter three groups may be optionally substituted and in which one or more of the carbons of the alkyl, cycloalkyl or aryl groups may optionally be replaced with O, S, N, NR2 or N(R2)2 or R1 is a bioactive agent;
• R2 is H, NH2, NH-Fmoc or C1-6alkyl;
• v and w are, independently of each other, an integer independently selected from 1 to 4.
• x is an integer between 10 and 300;
• y is an integer between 5 and 100;
• z is an integer between 0 and 100;
• wherein aryl is mono- or bicyclic aromatic radical containing from 6 to 14 carbon atoms having a single ring or multiple condensed rings;
• and
• wherein the optional substituents are selected from the group consisting of halo, OH, OC1-6alkyl, C1-6alkyl, C2-6alkenyl, C2-6alkenyloxy, NH2, NH(C1-6alkyl), N(C1-6alkyl)(C1-6alkyl), CN, NO2, C(O)C1-6alkyl, C(O)OC1-6alkyl, SO2C1-6alkyl, SO2NH2, SO2NHC1-6alkyl, phenyl and C1-6alkylenephenyl.