Modified globin proteins with altered electron transport pathway
AssigneeWivenhoe Technology Limited
InventorsChristopher Eric Cooper, Michael Thomas Wilson, Brandon Jon Reeder
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Abstract
The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids. The invention provides such proteins that comprise a modification to enhance this pathway.
Claims21
A modified porphyrin-based oxygen-carrying protein, said protein in an unmodified state comprising a low affinity site of electron transfer, and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids, wherein said protein comprises a modification to enhance or introduce a high affinity electron transfer pathway to the iron ion.
Dependencies are inferred from the claim text.