Novel OX40R Binding Agents

An isolated nucleic acid encoding a polypeptide consisting of:

• a) SEQ ID NO:
• 6;
• b) SEQ ID NO:
• 6, wherein one or more amino acids have been deleted, said polypeptide contains SEQ ID NO:
• 13 and said polypeptide binds to the OX40 receptor (OX40R);
• c) between 5 and 10 contiguous amino acids of SEQ ID NO:
• 1, wherein said polypeptide contains SEQ ID NO:
• 13 and binds to OX40R;
• d) SEQ ID NO:
• 8 or SEQ ID NO:
• 13;
• e) an active mutant of a), b), c) or d), wherein one or more of the amino acids has been conservatively substituted and said active mutant binds to OX40R;
• or
• f) a fusion polypeptide or peptide comprising a first amino acid sequence and a second amino acid sequence, wherein said first amino acid sequence is a protein sequence other than human OX40L fused to a second amino acid sequence selected from:
• i) SEQ ID NO:
• 6;
• ii) SEQ ID NO:
• 6, wherein one or more amino acids have been deleted, said second amino acid sequence contains SEQ ID NO:
• 13 and said fusion polypeptide binds to the OX40 receptor (OX40R);
• iii) between 5 and 10 contiguous amino acids of SEQ ID NO:
• 1, wherein said contiguous amino acids of SEQ ID NO:
• 1 contain SEQ ID NO:
• 13 and said fusion polypeptide binds to OX40R;
• or
• iv) SEQ ID NO:
• 8 or SEQ ID NO:
• 13.