US 2010/0136620 A1Published application

Soluble, stable form of hdm2, crystalline forms thereof and methods of use thereof

AssigneeSchering Corporation

InventorsShahriar Shane Taremi, Gaolian Xie, Thomas Hesson, Jose S. Duca, Corey Strickland, William T. Windsor, Vincent S. Madison, Rumin Zhang, Paul Reichert, Yaolin Wang

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Abstract

The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.

Claims9

Dependent claims

1-5. (canceled)

Dependencies are inferred from the claim text.

Facts

Application: 12/621,241Filed 18 Nov 2009
Priority: 10 Apr 2003
Published: 3 Jun 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07H 21/04
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
C07D 209/20
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals:…
C07K 14/47
From vertebrates: from mammals
C07K 2299/00
Coordinates from 3d structures of peptides

Family

Application60/461,787Us provisional application · filed 10 Apr 2003
Application60/547,265Us provisional application · filed 24 Feb 2004
Application10/822,254Division · filed 9 Apr 2004
Application12/621,241Division
US 2005/0037383 A1Published application
US 7,632,920 B2Related patent
US 8,034,907 B2Related patent
US 2010/0136620 A1This patent

From the US filing history. Foreign family members aren’t listed.

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