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AssigneeBristol-Myers Squibb Company
InventorsGlen Eugene Mikesell, Han Chang, Joshua N. Finger, Guchen Yang, Robert James Peach, Henry Shen
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The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
1-52. (canceled)
An isolated antibody or fragment thereof that binds to a polypeptide selected from the group consisting of:
An isolated antibody obtained from an animal that has been immunized with a polypeptide encoded by the cDNA of Clone BSL3 contained in ATCC deposit No. PTA-1986, wherein said antibody binds to an antigenic epitope-bearing polypeptide fragment comprising at least 5 contiguous amino acids of said polypeptide.
Dependencies are inferred from the claim text.