US 2010/0136030 A1 · ANTAGONIST OX40 ANTIBODIES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

Abstract

The present invention relates to antagonist antibodies directed against human OX40 receptor (CD134) and fragments thereof, including the amino acid sequences of antagonist antibodies and the nucleic acids that encode the antibodies. Also included in the present invention are antigen binding regions (CDRs) derived from the light and/or heavy chain variable regions of said antibodies. Another aspect of the present invention is the use of anti-OX40 antagonist antibodies in the treatment of inflammatory and autoimmune diseases. The present invention also relates to humanized sequences of an antagonist antibody A10 and epitope mapping of the binding site of the antibody.

Claims48

Dependent claims

An isolated antagonist antibody that specifically binds to a human OX40 epitope, said antibody comprising:

a. a heavy chain variable region (VH) comprising:
i. a VH CDR1 having the amino acid sequence of SEQ ID NO:17;
ii. a VH CDR2 having the amino acid sequence of SEQ ID NO:18;
and/or
iii. a VH CDR3 having the amino acid sequence of SEQ ID NO:19;
and/or
b. a light chain variable region (VL) comprising:
i. a VL CDR1 having the amino acid sequence of SEQ ID NO:12, 15 or 61;
ii. a VL CDR2 having the amino acid sequence of SEQ ID NO:13;
and/or
iii. (3) a VL CDR3 having the amino acid sequence of SEQ ID NO:14 or 16.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/526,550Filed 26 Feb 2008

Priority

27 Feb 2007

Published

3 Jun 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification35 codes

C07K 16/2878
Against receptors, cell surface antigens or cell surface determinants: against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics

Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases

Life of this patent

Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases

Life of this patent

Abstract

Claims48