Use of Tri-Substituted Glycerol Compounds for the Treatment of Hematological Malignancies
AssigneesUniversitätsklinikum Hamburg-Eppendorf, Alphaptose GmbH
InventorsAxel Rolf Zander, Francis Ayuk Ayuketang, Wolfgang Richter, Lutz Weber
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Abstract
The present invention relates to the use of a tri-substituted glycerol compound for the manufacture of a medicament for the treatment of hematological malignancies. The invention also refers to a kit-of-parts comprising such a medicament. Finally, the invention also relates to a corresponding method for the treatment of such conditions as well as to an in vitro method for determining the susceptibility of such malignant cells to a medicament as defined in the invention.
Claims21
1-29. (canceled)
Use of a tri-substituted glycerol compound according to formula (I)
- or an enantiomer or diastereomer or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient for the manufacture of a medicament for the treatment of hematological malignancies, wherein
- X is selected from the group consisting of phosphate and sulfate;
- R1 is selected from the group consisting of C16-C20 alkyl;
- R2 is selected from the group consisting of C1-C3 alkyl and C1-C3 hydroxyalkyl;
- R3 is selected from the group consisting of hydrogen and C1-C3 alkyl;
- R4 is selected from the group consisting of C1-C3 alkyl and C3-C6 cycloalkyl;
- and
- R5 is selected from the group consisting of hydrogen and methyl.
Dependencies are inferred from the claim text.