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US 2010/0135955 A1Published application
HUMAN M2e PEPTIDE IMMUNOGENS
AssigneeTheraclone Sciences, Inc.
InventorsMatthew Moyle, Jennifer Mitcham
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Abstract
The present invention provides novel peptide immunogens comprising influenza virus matrix 2 protein epitopes and related compositions and methods. The present invention relates to a composition comprising a peptide immunogen useful for the prevention and treatment of an influenza virus-mediated disease. The invention also relates to vaccines, immunogenic products and immunogenic compositions containing the peptide immunogens.
Claims29
A peptide immunogen comprising a sequence of:
- [Xaa0]m-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-[Xaa6]p-
- [Xaa7]q-[Xaa8-[Xaa0]m-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-
- [Xaa6]p-[Xaa7]q]n
- wherein, m, p and q are independently 0 or 1,
- n is any number between 0 and 4,
- Xaa0, Xaa6, Xaa7 and Xaa8 is independently any amino acid,
- Xaa1-Xaa2-Xaa3-Xaa0-Xaa5 is S-L-L-T-E, or a peptide having a single substitution to the sequence S-L-L-T-E, the substitution selected from the group consisting of:
- Xaa1 is C or T;
- Xaa2 is A, C, F or K,
- Xaa3 is A, C, E, F, I, K, M, Q, S, T or V, and
- Xaa5 is D or C.
8 more elements
A peptide immunogen comprising a sequence of:
- [Xaa0]m-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-[Xaa6]p-[Xaa7]q-
- [Xaa8-[Xaa0]m-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-[Xaa6]p-
- [Xaa7]q]n
- wherein, m, p and q are independently 0 or 1,
- n is any number between 0 and 4,
- Xaa0, Xaa6, Xaa7 and Xaa8 is independently any amino acid,
- Xaa1-Xaa2-Xaa3-Xaa4-Xaa5 is S-L-L-T-E, or a peptide having a single substitution to the sequence S-L-L-T-E, the substitution selected from the group consisting of:
- Xaa1 is A, C, D, L, T or V,
- Xaa2 is A, C, F, H, I, K, M, N, Q, R, T, W, or Y,
- Xaa3 is any amino acid,
- Xaa4 is M, N, Q, S, or W, and
- Xaa5 is A, D, F, H, I, K, M, N, Q, S, W, Y, or C.
9 more elements
Dependencies are inferred from the claim text.