Antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme

A storage-stable antimicrobial and immunostimulatory formulation comprising glucose oxidase, D-glucose, additional sugars selected from one or more of sucrose, fructose and/or maltose and hydrogen peroxide in an aqueous solution;

• wherein glucose oxidase is present at an activity of at least 10 U per 100 g of the formulation;
• D-glucose is present from 20 to 85% by weight based on the weight of the total formulation;
• additional sugars selected from one or more of sucrose, fructose and/or maltose are present from 5 to 70% by weight based on the weight of the total formulation;
• water is present from 10 to 20% by weight based on the weight of the total formulation;
• the system has a pH from approximately 4 to 8;
• and wherein the formulation provides a two-stage hydrogen peroxide release in which
• storage-stable endogenously produced hydrogen peroxide is bioavailable within the formulation at a level of at least 10 mg per litre for immediate release;
• and
• the sustained release of further hydrogen peroxide for at least a twenty-four hour period occurs upon rehydration of the formulation.

A storage-stable antimicrobial and immunostimulatory formulation containing glucose oxidase, D-glucose, sucrose, fructose, maltose and hydrogen peroxide in an aqueous solution and an optional buffering agent;

• wherein an effective amount of glucose oxidase is present at an activity of at least 10 U per 100 g of formulation;
• wherein the D-glucose is present from approximately 33% to approximately 43% by weight based on the weight of the total formulation;
• sucrose is present between 0.5% to 2.5% by weight based on the weight of the total formulation;
• fructose is present between 30% to 40% by weight based on the weight of the total formulation;
• maltose is present between 5% to 15% by weight based on the weight of the total formulation;
• water is present from 10 to 20% by weight based on the weight of the total formulation;
• an optional buffering agent in an effective amount of to achieve a formulation with a pH from approximately 4 to 8;
• and
• the formulation provides a two-stage hydrogen peroxide release in which
• storage-stable endogenously produced hydrogen peroxide is bioavailable within the formulation at a level of at least 10 mg per litre for immediate release and
• the sustained release of further hydrogen peroxide for at least a twenty-four hour period occurs upon rehydration of the formulation.