Magnetic cell and method of using the same

A method for localizing a magnetic cell to a site in a subject, the method comprising:

• administering a magnetic cell into a subject having a disease or a lesion, wherein the magnetic cell comprises a cell, a magnetic particle comprising a magnetic material, and a peptide which has an amino acid sequence comprising RGDS or GRGDS, and which has an adhesive activity for a cell surface molecule of the cell, wherein the magnetic particle is coated with the peptide;
• and
• applying a magnetic field at or near a site of the disease or the lesion so as to localize the magnetic cell at or near the site in the subject, wherein the magnetic field is applied outside the body of the subject, or by embedding a magnet inside the body of the subject.

A method for controlling the activity of a magnetic cell, the method comprising:

• administering a magnetic cell into a subject having an injury or lesion, wherein the magnetic cell comprises a cell, a magnetic particle comprising a magnetic material, a linker, and a drug for controlling the activity of the magnetic cell;
• applying a magnetic field at or near a site of the injury or lesion in the subject, and
• releasing the drug at or near the site so as to control the activity of the magnetic cell in the subject.

A method for inducing tissue repair in a subject, the method comprising:

• administering a magnetic cell into a subject in need of a tissue repair, wherein the magnetic cell comprises a cell, a magnetic particle comprising a magnetic material, and a linker;
• applying a magnetic field at or near a site of the tissue repair in the subject so as to retain the magnetic cell at or near the site of the tissue to be repaired, in an amount or duration sufficient to induce tissue repair.

A method for treating dementia in a subject, the method comprising:

• administering a magnetic cell to a subject having dementia, wherein the magnetic cell comprises a cell, a magnetic particle comprising a magnetic material and a linker;
• and
• applying a magnetic field to a region of the brain of the subject, in an amount and duration effective to treat the dementia.