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US 2010/0076021 A1Published application
Organic Compounds
OwnerHidetomo Imase, Masashi Kishidainventors
Life of this patent
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Abstract
The present invention provides a compound of formula (I): said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
Claims19
A compound of formula (I):
- R1 is substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted alkanoyl, or substituted or unsubstituted alkyl;
- R2 or R3 are independently of each other hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, halogen, cyano, nitro, hydroxyl, amino, NR′R″, wherein R′ and R″, independently of one another, represents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, or R′ and R″ form a 5-7-membered carbocyclic ring together with the nitrogen;
- or R2 and R3 may form together a 5-7-membered aromatic or heteroaromatic ring fused to the ring to which they are attached, whereby said 5-7-membered aromatic or heteroaromatic ring that may be substituted or unsubstituted;
- R4 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl alkyl or substituted or unsubstituted cycloalkyl;
- X is O or NR8;
- R5 or R8 are independently of each other hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl;
- or
- R5 and R8 can form together a 5-7-membered carbocyclic ring together with the nitrogen which ring can be substituted or unsubstituted;
- R6 and R7 are independently hydrogen, alkyl, haloalkyl, halogen, cyano, nitro, hydroxy, haloalkoxy, or alkoxy;
- or
- R6 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
- Y is N or CH;
- or a pharmaceutically acceptable salt thereof;
- or an optical isomer thereof;
- or a mixture of optical isomers.
12 more elements
19-21. (canceled)
Dependencies are inferred from the claim text.