Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer

A compound selected from the group consisting of:

• 1-(2-{5-Fluoro-4-[7-(2-fluoro-5-methylpyridin-4-yl)-benzo[b]thiophen-2-yl]-pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(2-Fluoro-5-methylpyridin-4-yl)-benzo[b]thiophen-2-yl]-5-methylpyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(2-Fluoro-5-methylpyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}-ethyl)imidazolidin-2-one,
• 1-{2-[5-Methyl-4-(7-pyridin-4-yl-benzo[b]thiophen-2-yl)pyrimidin-2-ylamino]-ethyl}imidazolidin-2-one,
• 1-(2-{5-Chloro-4-[7-(2-fluoro-5-methylpyridin-4-yl)benzo[b]thiophen-2-yl]-pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-{2-[5-Fluoro-4-(7-pyridin-4-yl-benzo[b]thiophen-2-yl)pyrimidin-2-ylamino]-ethyl}imidazolidin-2-one,
• 1-(2-{4-[7-(3-Ethoxypyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-(5-Fluoro-4-(7-(3-hydroxypyridin-4-yl)benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(2-Chloro-5-ethoxypyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}-ethyl)imidazolidin-2-one,
• 1-(2-{5-Fluoro-4-[7-(3-methoxypyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}-ethyl)imidazolidin-2-one,
• 1-(2-(5-Chloro-4-(7-(pyridin-4-yl)benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one,
• 1-(2-{5-Chloro-4-[7-(5-chloro-2-fluoropyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(2-Chloro-pyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{5-Chloro-4-[7-(2-chloro-pyridin-4-yl)benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(5-Chloro-2-fluoro-pyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(2-Chloro-5-fluoropyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}-ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(3-Chloro-pyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{5-Fluoro-4-[7-(3-methylpyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(5-Chloro-2-fluoropyridin-4-yl)-benzo[b]thiophen-2-yl]-5-methylpyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(2,5-Dichloropyridin-4-yl)-benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{5-Fluoro-4-[7-(2-fluoropyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(5-Chloro-2-fluoro-pyridin-4-yl)-benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 4-(2-(2-(2-(2-oxoimidazolidin-1-yl)ethylamino)pyrimidin-4-yl)benzo[b]thiophen-7-yl)picolinonitrile,
• 1-(2-{4-[7-(3-Amino-pyridin-4-yl)benzo[b]thiophen-2-yl]-5-fluoropyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(3-Methylamino-pyridin-4-yl)benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(3-Amino-pyridin-4-yl)benzo[b]thiophen-2-yl]-5-methylpyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(3-Amino-pyridin-4-yl)benzo[b]thiophen-2-yl]-pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(5-Amino-2-fluoropyridin-4-yl)benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{4-[7-(3-Amino-2-fluoropyridin-4-yl)benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one,
• 1-(2-{5-Fluoro-4-[7-(2-fluoro-5-hydroxymethyl-pyridin-4-yl)benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one, and
• 1-(2-{5-Fluoro-4-[7-(2-fluoro-5-(fluoromethyl)pyridin-4-yl)benzo[b]thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidin-2-one;
• or
• a pharmaceutically acceptable salt.

A method of treating cancer selected from the group consisting of non-small cell lung, oropharyngeal, oesophageal, gastric, melanoma, epidermoid carcinoma of the skin, breast, ovarian, endometrial, colorectal, neuroglioma, glioblastoma, thyroid carcinoma, cervical, pancreatic, prostate, hepatoblastoma and non-Hodgkin lymphoma cancers in a mammal comprising administering to a mammal in need of such treatment an effective amount of a compound of formula:

• wherein:
• R1 hydrogen, hydroxy, hydroxymethyl, halo, methyl, fluoromethyl, C1-C2 alkoxy, amino, or methylamino;
• R2 is hydrogen, halo, or cyano;
• R3 is hydrogen or halo;
• provided that at least one of R1, R2, and R3 is hydrogen;
• and
• R4 is hydrogen, halo, or methyl;
• or
• a pharmaceutically acceptable salt thereof.