Dicarbonylic compounds with antibacterial activity

A compound of general formula I,

• its stereoisomers and mixtures thereof, its polymorphs and mixtures thereof, N-oxides when there are oxidable nitrogen atoms, and the pharmaceutically acceptable solvates and addition salts of all of them, wherein:
• X represents —O—, —NH—, —S—, —NHC(═O)— or —NHC(═S)—;
• R1 represents —H, —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl, wherein —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl may be optionally substituted with one or more groups Ra;
• R2 represents —H, —ORb, —NRbRc, —(C1-C4)alkyl, —(C2-C4)alkenyl, —(C2-C4)alkynyl, or -Cy1 optionally substituted with one or more groups Rd or Re, wherein —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl may be optionally substituted with one or more groups Rd and/or one group Rf;
• R3 represents R1 or -Cy2 optionally substituted with one or more groups Ra or Rc;
• R4 represents —H, —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl, wherein —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl may be optionally substituted by one or more halogen atoms;
• alternatively, R3 and R4 may form together a 3- to 7-membered monocyclic ring, partially unsaturated, saturated or aromatic, containing from one to three heteroatoms independently selected from O, S and N, optionally substituted at any available position by one or more substituents Rc or halogen atoms;
• R5 and R6 independently represent —H or halogen;
• R7 represents R4 or heteroaryl optionally substituted with one or more groups Rc or halogen atoms, wherein heteroaryl represents a C- or N-radical of an aromatic 5- or 6-membered monocyclic ring containing from one to three heteroatoms independently selected from O, S and N;
• each Ra independently represents halogen, ═O, —ORc, —OC(═O)Rc, ═CRcRc, —CN, —C(═O)Rc, —C(═O)ORc, —C(═O)NRcRc, —NO2, —NRcRc, —NRcC(═O)Rc, —NRcC(═O)ORc or —NRcC(═O)NRcRc;
• Rb represents —H, Rg, —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl, wherein —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl may be optionally substituted with one or more groups Ra and/or one group Rg;
• each Rc independently represents —H, —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl, wherein —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl may be optionally substituted by one or more halogen atoms;
• each Rd independently represents halogen, ═CRaRc, ═CRcRc, —CN, —C(═O)Re′, —C(═O)ORe′, —C(═O)NRe′Rh′, —C(═O)SRe′, —C(═NRh′)NRe′Rh′, —C(═NRe′)NRh′Rh′, —C(═S)ORe′, —C(═O S)SRe′, —ORe′, ═O, —OC(═O)Re′, —OC(═O)NReRh′, —OC(═S)Re′, —O—N═O, —OSO2Re, —NRe′Rh′, ═NRe′, ═N—CN, ═N—ORe′, —N+Re′Rh′Rh′, —N═NRe′, —NRh′-NRe′Re′, —NRe′-NRe′Rh′, —N3, —N═O, —NRh′ORe′, —NRe′ORh′, —NO2, —NRe′C(═O)Rh′, —NRh′C(═O)Re′, —NRh′C(═O)ORe, —NRe′C(═O)ORh, —NRh′C(═O)NReRh′, —NRe′C(═O)NRhRh′, —NRe′C(═O)NRh′NRh′Rh′, —NRh′C(═O)NReNRh′Rh′, —NRh′C(═O)NRh′NRe′Rh′, —NRe′SO2Rh′, —NRh′SO2Re′, —SRe′, —SORe′, —SO2Re, —SO2NRe′Rh′ or —SO2ORe′;
• each Re independently represents Rf or —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl, wherein —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl may be optionally substituted with one or more groups Ra and/or one group Rg;
• each Re′ independently represents —H or —Re;
• each Rf independently represents -Cy1 optionally substituted with one or more groups Ra or Rh;
• each Rg independently represents -Cy1 optionally substituted with one or more groups Ra or Rc;
• each Rh independently represents —(C1-C4)alkyl, —(C2-C4)alkenyl or —(C2-C4)alkynyl, all of them optionally substituted with one or more groups Ra;
• each Rh′ independently represents —H or —Rh;
• Cy1 represents a C- or N-radical of a 3- to 7-membered monocyclic or 6- to 10-membered bicyclic ring system, partially unsaturated, saturated or aromatic, containing from one to three heteroatoms independently selected from O, S and N;
• and
• Cy2 represents a C- or N-radical of a 3- to 7-membered monocyclic ring, partially unsaturated, saturated or aromatic, containing from one to three heteroatoms independently selected from O, S and N.