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US 2010/0075912 A1Published application
Novel morphine derivatives
AssigneeNeorphys
InventorsKarine Larbouret, Roger Lahana, Cedric Castex
Life of this patent
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Abstract
The present invention relates to new morphine-6-glucuronide derivatives, to pharmaceutical compositions thereof and uses thereof.
Claims19
A compound of formula (A):
- wherein,
- the whole entity (A), except for substituent X, is designated as MR36G-NR1R2-S;
- R1 is a saturated or unsaturated C1-C10 alkyl group, linear or branched, substituted by one or several unsaturation(s), the alkyl chain being possibly interrupted by one or several heteroatom(s) chosen among O, S and N;
- R2 is a hydrogen, a saturated or unsaturated C1-C5 alkyl group, linear or branched, or an aryl, heteroaryl or a (C1-C5) alkylaryl group;
- R3 is a Y(C═Z)R or YR group, Y and Z representing independently oxygen or sulfur, R being a linear or branched, saturated or unsaturated C1-C6 alkyl group, provided that R3 is not O—CH3;
- X is a hydrogen, a radical —S—R4-W, or a radical MR36G-NR1R2-S,
- with R4 being a C1-C8 alkyl group, saturated or unsaturated, that may include amide, ester, and ether bonds and
- W being either a δ receptor antagonist or a K receptor antagonist,
- as well as one of its pharmaceutically acceptable salts.
6 more elements
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(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.