Repair of larynx, trachea, and other fibrocartilaginous tissues
AssigneeStryker Corporation
InventorsSlobodan Vukicevic, Vladimir Katic, Kuber T. Sampath
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Abstract
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Claims19
1-56. (canceled)
A method for repairing a defect locus in a ligament in a mammal comprising the step of providing to the defect locus a composition comprising an osteogenic protein selected from the group consisting of OP-1, OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, 60A protein, GDF-1, GDF-2, GDF-3, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11;
- and a biocompatible, bioresorbable carrier;
- thereby inducing the formation of functional replacement ligament tissue.
An implantable device for repairing a defect in a nonarticular cartilage tissue of a mammal, the device comprising an osteogenic protein selected from the group consisting of OP-1, OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, 60A protein, GDF-1, GDF-2, GDF-3, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11;
- and a biocompatible, bioresorbable carrier.
An implantable device for repairing a defect in a nonarticular cartilage tissue of a mammal, the device comprising an osteogenic protein, wherein the osteogenic protein comprises an amino acid sequence set forth in SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6 or SEQ ID NO:7;
- and a biocompatible, bioresorbable carrier.
Dependencies are inferred from the claim text.