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US 2010/0074890 A1Published application
Methods for identifying hcv protease inhibitors
AssigneeAvila Therapeutics, Inc.
InventorsMargit Hagel, Thia B. St. Martin, Mariana S. Nacht
Life of this patent
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Abstract
The present invention provides methods for identifying compounds useful as HCV protease inhibitors.
Claims30
A method comprising the steps of:
- (a) contacting a test compound with an NS3-containing protein;
- and
- (b) directly measuring a level of internal self-cleavage of the NS3.
A method comprising the steps of:
- (a) contacting a test compound with an HCV NS3;
- and
- (b) directly measuring a level of internal self-cleavage of the HCV NS3.
A method comprising the steps of:
- (a) contacting a cell with a test compound;
- (b) washing said cells at one or more time intervals;
- and
- (c) measuring internal self-cleavage of the HCV NS3 as compared to self-cleavage of HCV NS3 in the absence of said test compound.
1 more element
24-26. (canceled)
A kit for assaying the inhibitory activity of a compound on the self-cleavage of HCV NS3.
Dependencies are inferred from the claim text.