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US 2010/0063330 A1Published application
Paricalcitol purification
AssigneeAlphora Research Inc.
InventorsFabio Eduardo Silva e SOUZA, Ming PAN, Kathleen Da Silva TURCOT
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Abstract
Paricalcitol, a synthetic vitamin D analog, is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent, followed by filtration and vacuum drying. Isopropyl acetate appears to be unique among commonly available and pharmaceutically acceptable solvents in its ability to precipitate paricalcitol in this high purity, essentially free of isomers thereof.
Claims14
A process for purifying paricalcitol, which comprises:
- i. dissolving a solid impure paricalcitol composition in isopropyl acetate solvent;
- ii. and recovering purified paricalcitol from the solution by crystallization.
Dependencies are inferred from the claim text.