Pyridone derivatives as p38a mapk inhibitors
AssigneesAstellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.
InventorsChiyoshi Kasahara, Hitoshi Yamazaki
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Abstract
A compound represented by the formula (I): wherein R1 is lower alkyl, cycloalkyl or aromatic hydrocarbon ring, each of which is optionally substituted with one or more substituents; R2 is hydrogen atom, halogen atom, lower alkyl, halo(lower)alkyl or lower alkoxy; and R3 is (1) a group represented by the formula: wherein R4 is lower alkyl, etc.; (2) a group represented by the formula: wherein R5 is lower alkyl, etc.; (3) a group represented by the formula: wherein R6 is lower alkyl, etc.; or (4) a group selected from halogen atom, carboxy, hydroxy and lower alkoxy, or a salt thereof.
Claims7
A compound represented by the formula (I):
- wherein
- R1 is lower alkyl, cycloalkyl or aromatic hydrocarbon ring,
- each of which is optionally substituted with one or more substituents;
- R2 is halogen atom, lower alkyl, halo(lower)alkyl or lower alkoxy;
- and
- R3 is
- (1) a group represented by the formula:
- wherein
- R4 is lower alkyl, lower alkoxy, cycloalkyl, aromatic hetero ring, non-aromatic hetero ring or aromatic hydrocarbon ring, each of which is optionally substituted with one or more substituents;
- (2) a group represented by the formula:
- wherein
- R5 is lower alkyl, cycloalkyl, aromatic hydrocarbon ring, aromatic hetero ring or non-aromatic hetero ring, each of which is optionally substituted with one or more substituents;
- (3) a group represented by the formula:
- wherein
- R6 is lower alkyl, cycloalkyl, aromatic hydrocarbon ring or non-aromatic hetero ring, each of which is optionally substituted with one or more substituents;
- or
- (4) a group selected from halogen atom, carboxy, hydroxy and lower alkoxy,
- or a salt thereof.
Dependencies are inferred from the claim text.