Pyrimidine derivatives for the treatment of amyloid-related diseases

A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof:

• wherein
• X and Y are independently NR5 or O;
• W and Z are independently a bond or (CH2)mCH(R7)(CH2)n;
• m=0-1 and n=0-2;
• R1 and R2 are independently hydrogen, halogen, CF3, OR8, OR9, NR9R10, NR9COR11, NR9SO2R11, SO2NR9R10, SO2R11 or C1-6 alkyl optionally and independently substituted by one or more of hydroxyl, C1-6 alkoxy, halogen or NR9R10;
• R3 is hydrogen, halogen, CF3, OR8, COOR9, CONR9R10 or SO2R11;
• R4 is hydrogen, halogen, CF3, OR9, NR9R10, NR9COR11, NR9SO2R11, SO2NR9R10, or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10;
• or when R3 and R4 are positioned ortho and taken together form —O(CH2)nO—, where n is 1-3;
• R5 is hydrogen or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10;
• R6 is hydrogen, C1-6 alkyl, C1-6alkoxy or NR9R10;
• R7 is hydrogen, C1-6 alkyl, phenyl or C1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OCF3 or OR9;
• R8 is hydrogen or C1-6 alkyl optionally substituted by OR9 or NR9R10;
• R9 is hydrogen, C1-6 alkyl or C1-3 alkylphenyl wherein said phenyl group is optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OR8, NR9R10 or OCF3;
• R10 is hydrogen, C1-6 alkyl, C1-6 alkenyl, phenyl or C1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OR8 or OCF3;
• or the groups R9 and R10 when they are attached to a nitrogen atom may together form a 5- or 6-membered ring which optionally contains one further heteroatom selected from NR9, S and O;
• and
• R11 is C1-6 alkyl or a phenyl group optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OCF3 or OR8.