Compounds for the Treatment of Hepatitis C

A compound of formula I, II, III, IV, or V

• where:
• R1 is halo, alkyl, cycloalkyl, alkoxy, oxazolidinonyl, dioxothiazinyl, R5R6N,
• piperidinonyl substituted with 1
• substituent, pyrrolyl substituted with 1
• substituent, or phenyl where said phenyl is substituted with 1-2 substituents selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, carboxy, and CONR7R8, and where said phenyl is also substituted with 0-2 halo, alkyl, alkoxy, pyridinyl, phenyl or halophenyl substituents;
• R2 is hydrogen, halo, alkyl, cycloalkyl, alkoxy, or R5R6N;
• R3 is cyano, alkoxycarbonyl, (cycloalkyl)oxycarbonyl, (alkylsulfonyl)aminocarbonyl, CONR11R12, (R13)(R14)NCONH, triazolyl, thiazolyl, or tetrazolyl;
• R4 is phenyl substituted with 0-2 halo;
• R5 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, benzyl, alkylcarbonyl, haloalkylcarbonyl, phenylcarbonyl, (alkoxyphenyl)carbonyl, alkylsulfonyl, phenylsulfonyl, (alkoxyphenyl)sulfonyl or (haloalkoxyphenyl)sulfonyl;
• R6 is hydrogen, alkyl, hydroxyalkyl, or alkoxyalkyl;
• or R5 and R6 taken together with the nitrogen to which they are attached is oxazolidinonyl or dioxothiazinyl;
• R7 is hydrogen, alkyl,
• R8 is hydrogen or alkyl;
• R9 is hydrogen or alkyl;
• R10 is hydrogen or alkyl;
• or R9 and R10 taken together is ethylene, propylene, butylene, or pentylene;
• R11 is hydrogen or alkyl;
• R12 is hydrogen or alkyl;
• or R11 and R12 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
• R13 is hydrogen or alkyl;
• R14 is hydrogen or alkyl;
• or R13 and R14 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
• R15 is alkyl or cycloalkyl;
• R16 is hydrogen, halo, alkyl, or alkoxy;
• R17 is hydrogen, halo, alkyl, or alkoxy;
• and
• Ar1 is isoxazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, or phenyl, and is substituted with 0-1 halo, alkyl, or phenyl substituents;
• or a pharmaceutically acceptable salt thereof.