Carbonic anhydrase inhibitors derivatives

A compound of general formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof.

• R—(X—Y—ONO2)m (I)
• wherein:
• m is an integer equal to 1 or 2;
• R is:
• wherein
• R1 is —CH3 or —(CH2)3—OCH3;
• R2 is H or a group —(X—Y—ONO2),
• R′ is H or a group —(X—Y—ONO2);
• with the proviso that at least one of R2 or R′ is a —(X—Y—ONO2) group;
• A is a carbon or nitrogen atom;
• X is —CO—, —COO—;
• Y is a bivalent radical having the following meaning:
• (a)
• straight or branched Cl-C20 alkylene,
• straight or branched C1-C20 alkylene substituted with one or more of the substituents selected from the group consisting of:
• halogen atoms, hydroxy, —ONO2 or T, wherein T is —OC(O)(C,-C10 alkyl)-ONO2 or —O(C1-Clo alkyl)-ONO2;
• cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with side chains T1, wherein T1 is straight or branched C1-C1,3 alkyl;
• wherein n is an integer from 0 to 20, and n1 is an integer from 1 to 20;
• wherein
• X1=—OCO— or —COO—;
• Z is —(CH2)n1— or the bivalent radical defined above under b);
• n1 is as defined above and
• n2 is an integer from 0 to 2 and R3 is H or —CH3;
• wherein:
• Y1 is —CH2—CH2—CH2)n2a or —CH═CH—(CH2)n2a wherein n2a is from 0 to 2;
• Z, n1, n2, R3 and X1 are as defined above;
• wherein:
• n1 is an integer from 1 to 20 and R3 is H or —CH3,
• R0 is H or —COCH3;
• with the proviso that when Y is selected from the bivalent radicals mentioned under b)-f), then the terminal —ONO2 group is bound to —(CH2)n1,
• wherein X2 is -0- or —S—, n3 is an integer from 1 to 6, R3 is H or —CH3;
• wherein:
• n4 is an integer from 0 to 10;
• n5 is an integer from 1 to 10;
• R4, R5, R6, R7 are the same or different, and are H or straight or branched C1-C4 alkyl;
• wherein the —ONO2 group is linked to
• wherein n5 is as defined above;
• Y2 is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur,
• and is selected from the group consisting of: