Conjugated psychotropic drugs and uses thereof
AssigneesRamot at Tel-Aviv University Ltd., Bar-Ilan University
InventorsAbraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
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Abstract
Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
Claims17
1-24. (canceled)
A chemical conjugate comprising a phenothiazine being covalently linked to an organic acid having 3-5 carbon atoms in its backbone chain.
A chemical conjugate comprising perphenazine being covalently linked to γ-aminobutyric acid (GABA).
Dependencies are inferred from the claim text.