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US 2010/0063028 A1Published application
Triazabenzo[E]Azulene Derivatives for the Treatment Of Tumors
AssigneeMerck Patent Gesellschaft
InventorsGuenter Hoelzemann, Hartmut Greiner, Christiane Amendt
Life of this patent
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Abstract
Novel triazabenzo[e]azulene derivatives of the formula, (I) in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of TGF-beta receptor kinase and can be employed, inter alia, for the treatment of tumours.
Claims14
Compounds of the formula I
- in which
- R1 denotes H, A, OH, OA, NO2, NH2, NHA, NA2, Hal, CN, A-COO, COOH, COOA or CONR4R5,
- R2, R3 each, independently of one another, denote H, A, alkenyl having 2-6 C atoms, alkynyl having 2-6 C atoms or Hal,
- R4, R5 each, independently of one another, denote H or A,
- A denotes unbranched or branched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1-7 H atoms may be replaced by F,
- Hal denotes F, Cl, Br or I,
- and pharmaceutically usable derivatives, solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.
4 more elements
Dependencies are inferred from the claim text.