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OwnerAnders Jeppsson, Stanko Skrtic +3inventors
InventorsAnders Jeppsson, Stanko Skrtic, Lennart Bruce, Jörgen Johnsson, Thomas Hedner
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The present invention provides a method for preventing peri- and postoperative bleeding in subjects undergoing surgery, in particular subjects with a preoperative fibrinogen plasma level equal to or above the normal range. The method comprises administration of a substance with fibrinogen-like activity to the subject in an amount that result in a circulating fibrinogen plasma level of from about 1.0 g/L. The present invention also provides a method for determining the risk of subjects with a preoperative fibrinogen plasma level equal to or above the normal range to bleed postoperatively. Furthermore, the present invention provides means for predicting the necessity of blood or plasma transfusion after a subject with a preoperative fibrinogen plasma level equal to or above the normal range has been subject to a surgical procedure. The means involves measurement of the fibrinogen level of the subject before surgery and comparing the level with a risk curve.
1-60. (canceled)
A method for preventing perioperative and/or postoperative bleeding associated with a surgical procedure in a subject having a plasma fibrinogen level equal to or above a lower normal limit of 2 g/L, the method comprising administering fibrinogen to the subject in an amount that results in a circulating fibrinogen plasma level of from about 2 g/L to about 10 g/L.
A method for manufacturing a medication for inhibiting perioperative and/or postoperative bleeding associated with a surgical procedure, the method comprising preparing a pharmaceutical composition comprising fibrinogen.
A kit comprising:
A method for determining the risk of perioperative and/or postoperative bleeding in a subject that will undergo a surgical procedure, the method comprising:
A method for determining the risk of perioperative and/or postoperative bleeding in a subject that will undergo a surgical procedure, the method comprising:
A method for evaluating the potential need for a blood transfusion in a subject that will undergo a surgical procedure, the method comprising:
Dependencies are inferred from the claim text.