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US 2010/0062969 A1Published application
Hydrophilic polymer-conjugated lipids for peptide and protein folding disorders
OwnerHayat Onyuksel, Israel Rubinsteininventors
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OwnerHayat Onyuksel, Israel Rubinsteininventors
Estimating the term…
The present invention provides a method of correcting peptide or protein misfolding, which can be used to treat peptide and protein disorder in a mammalian subject. The method comprises administering to the mammalian subject, preferably a human subject, an effective amount of a composition comprising sterically stabilized simple micelles (SSM) of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles (SSMM) of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid. The composition may further comprise a biologically active compound, such as but not limited to vasoactive intestinal peptide (VIP), associated with the SSM or SSMM.
A method for treating a peptide and protein folding disorder in a mammalian subject, the method comprising administering to the mammalian subject an effective amount of a composition comprising sterically stabilized simple micelles of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid.
A method for treating Alzheimer's Disease (AD) in a mammalian subject by administering to the mammalian subject an effective amount of a composition comprising sterically stabilized simple micelles of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid.
A method for treating Alzheimer's Disease (AD) in a mammalian subject by administering an effective amount of a composition comprising of a biologically active compound of a member of glucagon/secretin family of peptides associated with sterically stabilized simple micelles of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid.
Dependencies are inferred from the claim text.