Nuclear reprogramming factor and induced pluripotent stem cells
AssigneeKyoto University
InventorShinya Yamanaka
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Abstract
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
Claims1
A method for preparing an induced pluripotent stem cell by nuclear reprogramming of a somatic cell, which comprises introducing the following four genes:
- Oct3/4, Klf4, c-Myc, and Sox2 into the somatic cell.
Dependencies are inferred from the claim text.