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US 2010/0041749 A1Published application
Organo-Arsenoxide Compounds and Use Thereof
AssigneeNewSouth Innovations Pty Limited
InventorsPhilip John Hogg, Pierre Dilda
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Abstract
The present invention relates to organo-arsenoxide compounds and to methods for their synthesis. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in the treatment of diseases and disorders, in particular proliferative diseases and disorders, including treatment of solid tumors and leukaemia.
Claims33
A compound of general formula (I):
- wherein
- the As(OH)2 group may be ortho-, meta- or para- to the N-atom on the phenyl ring;
- R1 is selected from hydrogen and C1-3 alkyl;
- R2 and R3 may be the same or different and are independently selected from hydrogen, optionally substituted C1-3 alkyl, optionally substituted cyclopropyl, optionally substituted C2-3 alkenyl;
- and optionally substituted C1-3 alkoxy;
- R4 and R5 may be the same or different and are independently selected from hydrogen, optionally substituted C1-3 alkyl, optionally substituted cyclopropyl, optionally substituted C2-3 alkylene;
- and optionally substituted C1-3 alkoxy;
- m is an integer selected from 1, 2 and 3;
- n is an integer selected from 1, 2 and 3;
- * indicates a chiral carbon atom;
- and
- salts and hydrates thereof, enantiomers and racemates thereof.
9 more elements
Dependencies are inferred from the claim text.