Anti-microbial orthodontic compositions and appliances and methods of production and use thereof

A kit, comprising:

• an anti-microbial orthodontic composition comprising:
• at least one of an adhesive, a sealant and a cement;
• an anti-microbial composition disposed in the at least one of an adhesive, a sealant and a cement, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of RSeH, RSeSeR, RSeSeR′, RSeSeH, and RSeX, wherein R and R′ are organic residues that allow formation of the selenium anion Se— and free radical species and that provide permanent attachment of the selenium anion Se— to a surface to which the anti-microbial orthodontic composition is applied, and wherein X is a protecting group selected from the group consisting of a halogen, an imide, a cyanide, an azide, a phosphate, a sulfate, a nitrate, a carbonate, selenium dioxide, and combinations thereof;
• and
• an activator.

A kit, comprising:

• an orthodontic device;
• and
• an anti-microbial orthodontic composition comprising:
• at least one of an adhesive, a sealant and a cement;
• an anti-microbial composition disposed in the at least one of an adhesive, a sealant and a cement, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of RSeH, RSeSeR, RSeSeR′, RSeSeH, and RSeX, wherein R and R′ are organic residues that allow formation of the selenium anion Se— and free radical species and that provide permanent attachment of the selenium anion Se— to a surface of the orthodontic device, and wherein X is a protecting group selected from the group consisting of a halogen, an imide, a cyanide, an azide, a phosphate, a sulfate, a nitrate, a carbonate, selenium dioxide, and combinations thereof.

A method of producing an anti-microbial orthodontic composition, comprising the steps of:

• providing an orthodontic composition;
• providing an anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of RSeH, RSeSeR, RSeSeR′, RSeSeH, and RSeX, wherein R and R′ are organic residues that allow formation of the selenium anion Se— and free radical species and that provide permanent attachment of the selenium anion Se— to a surface to which the orthodontic composition is applied, and wherein X is a protecting group selected from the group consisting of a halogen, an imide, a cyanide, an azide, a phosphate, a sulfate, a nitrate, a carbonate, selenium dioxide, and combinations thereof;
• and
• disposing the anti-microbial composition into the orthodontic composition to provide an anti-microbial orthodontic composition.

A method of binding an orthodontic device to a tooth, comprising the steps of:

• providing a tooth;
• providing an orthodontic device;
• providing an anti-microbial orthodontic composition comprising:
• at least one of an adhesive and a cement;
• an anti-microbial composition disposed in the at least one of an adhesive, a sealant and a cement, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of RSeH, RSeSeR, RSeSeR′, RSeSeH, and RSeX, wherein R and R′ are organic residues that allow formation of the selenium anion Se— and free radical species and that provide permanent attachment of the selenium anion Se— to a surface of at least one of the orthodontic device and the tooth, and wherein X is a protecting group selected from the group consisting of a halogen, an imide, a cyanide, an azide, a phosphate, a sulfate, a nitrate, a carbonate, selenium dioxide, and combinations thereof;
• and
• binding the orthodontic device to the tooth with an effective amount of the anti-microbial orthodontic composition, whereby the anti-microbial orthodontic composition prevents the growth of microbes on at least one of the orthodontic device and the tooth.

A method of binding an anti-microbial device to a tooth, comprising the steps of:

• providing a tooth;
• providing an anti-microbial orthodontic apparatus, comprising:
• an orthodontic device;
• an anti-microbial coating applied to the orthodontic device, wherein the anti-microbial coating comprises an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of RSeH, RSeSeR, RSeSeR′, RSeSeH, and RSeX, wherein R and R′ are organic residues that allow formation of the selenium anion Se— and free radical species and that provide permanent attachment of the selenium anion Se— to a surface of the orthodontic device, and wherein X is a protecting group selected from the group consisting of a halogen, an imide, a cyanide, an azide, a phosphate, a sulfate, a nitrate, a carbonate, selenium dioxide, and combinations thereof;
• and
• binding the anti-microbial orthodontic apparatus to the tooth, whereby the anti-microbial coating prevents the growth of microbes on the orthodontic device.

A method of applying an antimicrobial coating to a tooth, comprising the steps of:

• providing a tooth;
• providing an anti-microbial dental composition comprising a sealant having an anti-microbial composition disposed therein, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of RSeH, RSeSeR, RSeSeR′, RSeSeH, and RSeX, wherein R and R′ are organic residues that allow formation of the selenium anion Se— and free radical species and that provide permanent attachment of the selenium anion Se— to a surface of the tooth, and wherein X is a protecting group selected from the group consisting of a halogen, an imide, a cyanide, an azide, a phosphate, a sulfate, a nitrate, a carbonate, selenium dioxide, and combinations thereof;
• and
• disposing an effective amount of the anti-microbial dental composition on at least a portion of the tooth, thereby preventing the growth of microbes on the tooth.