Prion-free transgenic ungulates
OwnerDeborah J. Good, Jose Cibelliinventors
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Abstract
Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion protein, and are not susceptible to prion-related diseases such as bovine spongiform encephalopy or Mad Cow Disease.
Claims31
A transgenic ungulate bearing a homozygous deletion of the prion gene, wherein said deletion renders the ungulate less susceptible to prion-related diseases.
(canceled)
An isolated DNA molecule comprising at least part of an ungulate prion gene promoter operably linked to either a selectable marker gene coding region or a reporter gene coding region.
11-21. (canceled)
28-29. (canceled)
A transgenic ungulate bearing a heterozygous deletion of the prion gene, wherein said deletion prevents expression of a functional endogenous prion protein from one prion gene allele, and wherein lack of expression of a functional endogenous prion protein from said one allele renders said ungulate less susceptible to prion-related diseases.
(canceled)
33-38. (canceled)
(canceled)
45-48. (canceled)
A transgenic ungulate bearing a homozygous disruption of the prion gene, wherein said disruption renders the ungulate less susceptible to prion-related diseases.
Dependencies are inferred from the claim text.