Process for resolving racemic mixtures and a diastereoisomeric complex of a resolving agent and an enantiomer of interest

A process for resolving a compound in racemic form comprising the following steps:

• a) reacting a compound in racemic form with a resolving agent,
• b) obtaining the formation of a diastereoisomeric complex of said resolving agent and an enantiomer of interest,
• c) separating the enantiomer of interest from the obtained diastereoisomeric complex,
• characterized in that
• said resolving agent is a compound selected from the group consisting of:
• i) a compound of Formula II
• or a compound of Formula III
• wherein R1 is a C1-C3 alkyl;
• A is a substituent selected from the group consisting of —CH2—, —SO2 and —C═O.
• p is 0 or 1,
• CR is a C6-C12 aromatic group optionally substituted with one or more halogens;
• ii) a compound of Formula IV
• or a compound of Formula V
• wherein R1 is a C1-C3 alkyl;
• A is a substituent selected from the group consisting of —CH2—, —SO2 and —C═O.
• p is 0 or 1,
• CR is a C6-C12 aromatic group optionally substituted with one or more halogens;
• iii) a compound of Formula VI
• or a compound of Formula VII
• wherein p is 1
• A is a methylenic moiety —CH2— or —C═O,
• R1 is a C1-C3 alkyl,
• R2 is —CH2OH or —COOH and
• CR is a C6-C12 aromatic group optionally substituted with one or more halogens.

A diastereoisomeric complex of an enantiomer and a resolving agent, which is selected from the group consisting of:

• i) a compound of Formula II
• or a compound of Formula III
• wherein R1 is a C1-C3 alkyl;
• A is a substituent selected from the group consisting of —CH2—, —SO2 and —C═O.
• p is 0 or 1,
• CR is a C6-C12 aromatic group optionally substituted with one or more halogens;
• ii) a compound of Formula IV
• or a compound of Formula V
• wherein R1 is a C1-C3 alkyl;
• A is a substituent selected from the group consisting of —CH2—, —SO2 and —C═O.
• p is 0 or 1,
• CR is a C6-C12 aromatic group optionally substituted with one or more halogens;
• iii) a compound of Formula VI
• or a compound of Formula VII
• wherein p is 1
• A is a methylenic moiety —CH2— or —C═O,
• R1 is a C1-C3 alkyl,
• R2 is —CH2OH or —COOH and
• CR is a C6-C12 aromatic group optionally substituted with one or more halogens.