Novel Quinazoline Derivatives and Their Medical Use

A quinazoline derivative of Formula I

• any of its stereoenantiomers or any mixture of its stereoenantiomers, or a pharmaceutically-acceptable addition salt thereof, or an N-oxide thereof, wherein
• R1 represents hydrogen or alkyl;
• and
• R2 represents alkyl, cycloalkyl, halo, haloalkyl, hydroxyalkyl, hydroxy, alkoxy, phenyl, phenylalkyl, amino, alkyl-carbonyl-amino, cyano or nitro;
• or
• R1 and R2 together with the carbon atom to which they are attached form a cycloalkyl group;
• or
• R1 represents hydrogen;
• and
• R2 together with R3 attached in ortho-position on the aromatic ring form a —(CH2)n— bridge, wherein n is 1, 2 or 3;
• R3 and R4, independently of each other, represent hydrogen, alkyl, cycloalkyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, amino, alkyl-carbonyl-amino, alkyl-sulfonyl, phenyl, benzoyl, cyano or nitro;
• or
• R3 and R4 together form a methylenedioxy group;
• or
• R3 attached in ortho-position on the aromatic ring and together with R2 form a —(CH2)n— bridge, wherein n is 1, 2 or 3;
• and
• R4 is as defined above;
• R5 represents alkyl, cycloalkyl, alkoxy, alkylthio or phenyl;
• and
• R6 and R7, independently of each other, represent hydrogen, alkyl, cycloalkyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, amino, alkyl-carbonyl-amino(acetamido), nitro, cyano or phenyl;
• provided, however, that if R1 is hydrogen, R2 is methyl, R3 and R4 represent hydrogen, R5 is isopropyl, and R6 and R7 represent hydrogen, then the compound it is not a quinazoline derivative racemate but the R- or S-enantiomer of the quinazoline derivative.