Back to results
US 2009/0286963 A1Published application
Antigenic fusion protein carrying gal alpha1,3gal epitopes
AssigneeRecopharma AB
InventorsJan Holgersson, Jining Liu
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeRecopharma AB
InventorsJan Holgersson, Jining Liu
Estimating the term…
The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of a hyperacute rejection reaction in a patient who is to receive a xenotransplant.
An absorber comprising a dimerized fusion polypeptide comprising a first polypeptide operably linked to a second polypeptide, wherein the first polypeptide:
The absorber of claim 14, wherein the fusion polypeptide comprises multiple Galα1,3Gal epitopes.
Dependencies are inferred from the claim text.