Polymorphic forms of ladostigil tartrate
AssigneeTeva Pharmaceutical Industries USA, Inc.
InventorsJudith ARONHIME, Eliezer Bahar, Anton Frenkel, Ronen Gottesfeld, Amir Gold, Tamas Koltai
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Abstract
The invention provides for solid state chemistry of ladostigil tartrate, particularly polymorphic forms of ladostigil tartrate, and processes for the preparation thereof.
Claims21
A crystalline ladostigil tartrate characterized by an x-ray diffraction pattern having peaks at 8.7, 13.9, 18.0, 18.4, 19.5, 22.9, and 23.1±0.2 degrees two theta.
A crystalline ladostigil tartrate characterized by an x-ray diffraction pattern selected from the group consisting of:
- a) an x-ray diffraction pattern having peaks at 4.3, 5.6, 11.2, 13.0, 16.8, and 19.9±0.2 degrees two theta;
- b) an x-ray diffraction pattern having peaks at 5.8, 10.8, 13.3, 17.4, 23.6±0.2 degrees two theta;
- c) by an x-ray diffraction pattern having peaks at 4.9, 8.7, 12.0, 13.6, and 18.9±0.2 degrees two theta;
- d) an x-ray diffraction pattern having peaks at 3.3, 6.4, 13.0, 13.3, and 19.6±0.2 degrees two theta;
- e) an x-ray diffraction pattern with peaks at 4.4, 8.5, 10.5, 15.6 and 17.7±0.2 degrees two theta;
- f) an x-ray diffraction pattern with peaks at 6.5, 12.0, 13.0, 13.3 and 18.6±0.2 degrees two theta;
- g) by an x-ray diffraction pattern having peaks at 6.3, 12.2, 12.7 and 24.7±0.2 degrees two theta;
- h) an x-ray diffraction pattern having peaks at 3.5, 6.5, 12.8, 19.3, and 21.1±0.2 degrees two theta;
- i) an x-ray diffraction pattern having peaks at 6.4, 12.1, 12.8, and 14.6±0.2 0.2 degrees two theta;
- and
- j) an x-ray diffraction pattern having peaks at 4.5, 8.9, 11.4, 14.6, and 18.4±0.2 degrees two theta.
Solid ladostigil tartrate in amorphous form.
A pharmaceutical composition comprising a therapeutically effective amount of a form of ladostigil tartrate selected from the group consisting of A, B, C, E, F, H, I, J, J1, K, L and amorphous form and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.