US 2009/0275608 A1 · Methods of diagnosing and treating parp-mediated diseases

Abstract

Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression of differentially expressed genes, including at least PARP, in a plurality of samples from a population, making a decision regarding identifying the disease treatable by modulators to the differentially expressed genes wherein the decision is made based on the level of expression of the differentially expressed genes. The method can further comprise treating the disease in a subject population with modulators of identified differentially expressed genes. The methods relate to identifying up-regulated expression of identified differentially-expressed genes in a disease and making a decision regarding the treatment of the disease. The level of expression of the differentially expressed genes in a disease can also help in determining the efficacy of the treatment with modulators to the differentially expressed genes.

Claims75

Dependent claims

A method of identifying genes useful in the treatment of a patient with a disease susceptible to PARP modulator treatment, the method comprising:

a. identifying a disease treatable with at least one PARP modulator, wherein the expression level of PARP in a plurality of samples from a population is regulated in comparison to a control sample;
b. determining the expression level of a panel of genes in the plurality of samples;
and
c. identifying genes that are co-regulated with said PARP regulation, wherein the expression level of said co-regulated genes in the plurality of samples are increased or decreased in comparison to a control sample;
wherein modulation of said genes that are co-regulated with PARP regulation is useful in the treatment of a disease susceptible to PARP modulator treatment.

2 more elements

A method of treating a patient with a disease susceptible to PARP modulator treatment, the method comprising:

a. identifying a disease treatable with at least one PARP modulator, wherein the expression level of PARP in a sample from a patient with said disease is regulated in comparison to a reference sample;
b. identifying at least one co-regulated gene in said sample in comparison to a reference sample;
c. treating said patient with modulators to PARP and the co-regulated gene.

A method of treating a disease susceptible to PARP modulator treatment, the method comprising:

a. identifying a disease treatable with at least one PARP modulator, wherein the expression level of PARP in a plurality of samples is regulated in comparison to a reference sample;
b. identifying at least one co-regulated gene in said plurality of samples in comparison to a reference sample;
c. treating a patient with said disease with modulators to PARP and the co-regulated gene.

A method of treating a cancer susceptible to PARP inhibitor treatment, the method comprising:

a. identifying a cancer treatable with at least one PARP inhibitor, wherein the expression level of PARP in a plurality of cancer samples is up-regulated;
b. identifying at least one co-upregulated gene in said plurality of samples;
c. treating a patient with said cancer with inhibitors to PARP and the co-regulated gene.

A method of treating a breast cancer susceptible to PARP inhibitor treatment, the method comprising

a. identifying a breast cancer treatable with at least one PARP inhibitor, wherein the expression level of PARP in a plurality of breast cancer samples is up-regulated;
b. identifying at least one co-upregulated gene in said plurality of samples;
c. treating a patient with said breast cancer with inhibitors to PARP and the co-regulated gene.

A method of treating a lung cancer susceptible to PARP inhibitor treatment, the method comprising:

a. identifying a lung cancer treatable with at least one PARP inhibitor, wherein the expression level of PARP in a plurality of lung cancer samples is up-regulated;
b. identifying at least one co-upregulated gene in said plurality of samples;
c. treating a patient with said lung cancer with inhibitors to PARP and the co-regulated gene.

A method of treating an endometrial cancer susceptible to PARP inhibitor treatment, the method comprising:

a. identifying an endometrial cancer treatable with at least one PARP inhibitor, wherein the expression level of PARP in a plurality of endometrial cancer samples is up-regulated;
b. identifying at least one co-upregulated gene in said plurality of samples;
c. treating said patient with inhibitors to PARP and the co-regulated gene.

A method of treating an ovarian cancer susceptible to PARP inhibitor treatment, the method comprising:

a. identifying an ovarian cancer treatable with at least one PARP inhibitor, wherein the expression level of PARP in a plurality of ovarian cancer samples is up-regulated;
b. identifying at least one co-upregulated gene in said plurality of samples;
c. treating said patient with inhibitors to PARP and the co-regulated gene.

Dependencies are inferred from the claim text.

Methods of diagnosing and treating parp-mediated diseases

Life of this patent

Methods of diagnosing and treating parp-mediated diseases

Life of this patent

Abstract

Claims75