Compounds and methods for activated therapy

A method for activated therapy comprising administering to a subject in need thereof a compound having formula I:

• or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein R is OR4 or NR4R5 and each R4 and R5 is independently selected from hydrogen, a substituted or unsubstituted, saturated or unsaturated alkyl group or a substituted or unsubstituted aryl group;
• alternatively, R4 and R5 can be taken together with the nitrogen they are attached to form a substituted or unsubstituted heterocyclic group;
• each R1 is independently selected from a substituted or unsubstituted, saturated or unsaturated alkyl group, a substituted or unsubstituted aryl group, acid, ester, amide, amine, substituted amine, acyl, hydroxy, ether, halogen, nitrile, aldehyde, thiol, thioether, sulfonic acid, sulfonate, sulfonamide, and sulfate;
• R2 and R3 are independently selected from hydrogen, a substituted or unsubstituted, saturated or unsaturated alkyl group;
• n is zero or an integer from 1 to 10;
• represents a single or double bond;
• M represents a metal at oxidation state I-VII;
• X is an anion or is selected from the group consisting of F, Cl, Br, I, H, CN, a substituted or unsubstituted hydroxide group, a substituted or unsubstituted amino group, a substituted or unsubstituted, straight or branched C1-C20 alkyl group, an acyl group, a thiolate group or a dialkylamino group;
• and
• m represents 0, 2, 3, 4 or 5 and is chosen to maintain the electric neutrality of the metal complex compound;
• and
• subjecting the individual to ultrasound or red light.