Normalization Probes for Comparative Genome Hybridization Arrays
AssigneeAgilent Technologies, Inc.
InventorsJing Gao, B. Shane Giles, Peter G. Webb, Douglas N. Roberts
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Abstract
A method of selecting a set of normalization probes for use on a comparative genome hybridization array is provided. In certain embodiments, the method includes: a) selecting a first region of a genome to be evaluated by comparative genome hybridization to produce data; b) selecting a second region of the genome for normalization of the data, and c) selecting from a set of candidate probes a sub-set of normalization probes that detect the second region.
Claims28
A method of selecting a set of normalization probes for use on a comparative genome hybridization array, comprising:
- a) selecting a first region of a genome to be evaluated by comparative genome hybridization to produce data;
- b) selecting a second region of said genome for normalization of said data, and
- c) selecting from a set of candidate probes a sub-set of normalization probes that detect said second region;
- to select said set of normalization probes.
A method of producing an array, comprising:
- a) selecting a first set of probes for producing data indicating the copy number of a first region of a genome;
- b) selecting a second region of said genome for normalization of said data,
- c) selecting from a set of candidate probes a sub-set of normalization probes that detect said second region;
- and
- d) fabricating an array comprising said first set of probes and said set of normalization probes;
- to produce said array.
A computer-based method for selecting a set of normalization probes for a comparative genome hybridization (CGH) array, comprising the following acts:
- inputting a region of a genome for data normalization;
- and,
- executing computer readable instructions for selecting from a set of candidate probes a sub-set of normalization probes that detect said second region;
- to select said set of normalization probes for said CGH array.
Dependencies are inferred from the claim text.