Pancreatic Cancer Genes
AssigneeChiron Corporation, a Delaware corporation
InventorGiulia Kennedy
Life of this patent
Estimating the term…
Abstract
The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
Claims3
A method of diagnosing dysplasia in a patient comprising comparing the amount of a polypeptide in a patient sample and in a normal sample, wherein said polypeptide comprises the polypeptide encoded by SEQ ID NO:13, or a naturally occurring variant of SEQ ID NO:13, wherein said naturally occurring variant hybridizes to SEQ ID NO:13 under conditions including a wash in 2×SCC, 0.1% SDS at 50° C. for 20 minutes;
- and wherein a patient sample containing more of said polypeptide than the normal sample is identified as dysplastic.
The method of claim 2, wherein the dysplasia is pancreatic dysplasia.
Dependencies are inferred from the claim text.