Reprogramming a cell by inducing a pluripotent gene through use of an HDAC modulator

A method for reprogramming a cell comprising:

• exposing a cell to a first agent that inhibits that activity, expression, or expression and activity of a HDAC;
• exposing said cell to a second agent that inhibits the activity, expression or expression and activity of a second regulatory protein, wherein said second regulatory protein has a distinct function from the HDAC, inducing expression of a pluripotent gene, and selecting a cell, wherein differentiation potential has been restored to said cell.

An enriched population of reprogrammed cells produced according to a method comprising the steps of:

• exposing a population of cells to an agent that inhibits activity, expression of activity and expression of a histone deacetylase;
• inducing expression of a pluripotent gene;
• selecting a cell that express a cell surface marker indicative of a pluripotent cell, and expanding said selected cell to produce a population of cells, wherein differentiation potential has been restored to said cell