Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof

The process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide represented by Formula (1)

• or a salt thereof, the process comprising the steps of reacting n-octylamine represented by Formula (4)
• H2N—(CH2)7CH3 (4)
• or a salt thereof, with a compound represented by Formula (5)
• M—N(CN)2 (5)
• wherein M is an alkali metal, or a salt thereof, in an ester-based organic solvent to obtain 1-cyano-3-octylguanidine represented by Formula (2)
• or a salt thereof;
• and reacting the 1-cyano-3-octylguanidine or salt thereof obtained in the above step with 3,4-dichlorobenzylamine represented by Formula (3)
• or a salt thereof, in an ester-based organic solvent.

A process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide represented by Formula (1)

• or a salt thereof, the process comprising reacting n-octylamine represented by Formula (4)
• H2N—(CH2)7CH3 (4)
• or a salt thereof, with a compound represented by Formula (5)
• M—N(CN)2 (5)
• wherein M is an alkali metal, or a salt thereof, in an ester-based organic solvent to form 1-cyano-3-octylguanidine represented by Formula (2)
• or a salt thereof;
• and subsequently, without isolating the 1-cyano-3-octylguanidine or salt thereof, adding 3,4-dichlorobenzylamine represented by Formula (3)
• or a salt thereof, to the reaction mixture to thereby react the 1-cyano-3-octylguanidine or salt thereof with the 3,4-dichlorobenzylamine or salt thereof.