Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate

A process for the preparation of 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile of formula I,

• the process comprising reacting 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile of formula II
• with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine.

A process for the preparation of 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile of formula I, the process comprising:

• (a) reacting a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II;
• (b) precipitating 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent, and (c) reacting the 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile with 4-fluorobenzonitrile in dimethylformamide in the presence of potassium tertiary butoxide.

A process for the preparation 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile of formula I, the process comprising:

• (a) reacting a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II;
• (b) precipitating 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent;
• and (c) reacting 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine.

25-26. (canceled)