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AssigneesMedical Research Council, University of Cape Town Observatory, The University of North Carolina at Chapel Hill, AlphaVax, Inc.
InventorsRobert Edward Johnston, Salim Abdol Karim, Lynn Morris, Ronald Swanstrom, Carolyn Williamson
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Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. A process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.
An isolated nucleic acid molecule comprising a sequence that encodes an HIV Gag polypeptide as set forth in SEQ ID NO:
A polypeptide comprising the Gag sequence as set forth in SEQ ID NO:
A composition comprising a nucleic acid molecule comprising a sequence that encodes an HIV Gag polypeptide as set forth in SEQ ID NO:
Dependencies are inferred from the claim text.