Aminophenyl derivatives as selective androgen receptor modulators
OwnerNathalie Schlienger, Mikkel Boas Thygesen +5inventors
InventorsNATHALIE SCHLIENGER, Mikkel Boas Thygesen, Jan Pawlas, Fabrizio Badalassi, Rasmus Lewinsky, Birgitte Winther Lund, Roger Olsson
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Abstract
Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein R1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
Claims19
A compound selected from the group consisting of:
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile;
- a prodrug ester thereof,
- a stereoisomer thereof,
- a pharmaceutically acceptable salt thereof,
- and/or a combination thereof.
A pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of:
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile;
- a prodrug ester thereof,
- a stereoisomer thereof,
- a pharmaceutically acceptable salt thereof,
- and/or a combination thereof.
A compound selected from the group consisting of:
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile;
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile hydrochloride;
- and
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile mesylate.
A pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of:
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile;
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile hydrochloride;
- and
- 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile mesylate.
Dependencies are inferred from the claim text.