2-Aryl-and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof

A compounds of formula I:

• and pharmaceutically acceptable salts thereof,
• wherein
• A is H, C1-C3 alkyl, or acetyl;
• Z is NR3 or O;
• Q is —NR1R2, —NR3N(R3)2, —NR3OR3, or —OH;
• R1 and R2 are each independently H or C1-C3 alkyl, or R1 and R2 join together with the nitrogen atom to which each is attached, forming a 4 to 6 membered saturated heterocyclic ring comprising heteroatoms selected from 1-2 nitrogen atoms, 0-1 oxygen atom and 0-1 sulfur atom, said ring optionally substituted with one or more of R4;
• R3 at each occurrence is independently H or C1-C3 alkyl;
• R4 is C1-C3 alkyl, —N(R3)2, or —OH;
• Y1, Y2, Y3, and Y4 are the same or different, and are each independently N or CR5, or two R5 groups on adjacent carbon atoms join together, with the carbon atoms which they are bonded, to form a 9 to 10 membered bicyclic aryl ring or bicyclic heteroaryl ring, said ring comprising members selected from CR5 and N;
• R5 is independently H or is independently selected from C1-C3 alkyl, F, Cl, Br, I, CF3, NO2, —NR1R2, —CHO, —CONHAr, —C(R3)2OR3, —C(R3)2O[C(R3)2]Ar, —C(R3)2NR1R2, —C(R3)2NR3[C(R3)2]2NR1R2, —CO2R6, —SOR6, and —SO2R6, where Ar is phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl, 2-furyl, or 3-furyl, optionally substituted with one or more of R4;
• R6 is independently H or is independently selected from C1-C8 alkyl, C2-C8 alkenyl, and C2-C8 alkynyl, each optionally substituted with —NR1R2, —OR3, C4-C6 cycloalkyl, a saturated heterocyclic ring comprising heteroatoms selected from 0-1 nitrogen atom, 0-1 oxygen atom and 0-1 sulfur atom, or —COCH3, C4-C6 cycloalkyl, optionally substituted with R4;
• or a saturated heterocyclic ring comprising heteroatoms selected from 0-1 nitrogen atom, 0-1 oxygen atom and 0-1 sulfur atom, and optionally substituted with one or more of R4;
• and
• m is 0 or 1.